Yutaka Hayashi Selected Research

N- (4- methoxybenzyl)- N'- (5- nitro- 1,3- thiazol- 2- yl)urea

10/2013	Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling.
2/2009	Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma.

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Yutaka Hayashi Research Topics

Disease

35	Neoplasms (Cancer) 01/2020 - 06/2002
15	Glioma (Gliomas) 01/2020 - 05/2010
15	Glioblastoma (Glioblastoma Multiforme) 04/2017 - 03/2005
4	Hydrocephalus (Hydrocephaly) 01/2013 - 01/2010
4	Hepatoblastoma 02/2007 - 05/2003
3	Brain Neoplasms (Brain Tumor) 03/2017 - 03/2005
3	Neuroblastoma 04/2008 - 06/2002
3	Biliary Atresia 12/2005 - 02/2003
3	Spasm (Spasms) 12/2004 - 09/2003
2	Hepatocellular Carcinoma (Hepatoma) 01/2020 - 01/2013
2	Urinary Tract Infections (Urinary Tract Infection) 12/2017 - 12/2007
2	Vesico-Ureteral Reflux (Vesicoureteral Reflux) 12/2017 - 10/2006
2	Lymphoma (Lymphomas) 07/2015 - 11/2009
2	Meningioma (Meningiomas) 05/2012 - 02/2009
2	Cerebral Hemorrhage 11/2010 - 01/2010
2	Medulloblastoma 11/2010 - 03/2005
2	Aneurysm (Aneurysms) 01/2010 - 12/2009
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 11/2009 - 01/2002
2	Adrenocortical Carcinoma 01/2009 - 02/2003
2	Adrenocortical Adenoma (Disease, Conn's) 01/2009 - 02/2003
2	Cholangitis 08/2007 - 12/2004
2	Hemorrhage 08/2007 - 01/2002
2	Short Bowel Syndrome 11/2006 - 03/2006
2	Pheochromocytoma 02/2003 - 06/2002
2	Ganglioneuroblastoma 02/2003 - 06/2002
1	Pathologic Constriction (Stenosis) 07/2021
1	Hematoma 01/2020
1	Combined Pituitary Hormone Deficiency 01/2018
1	Neurogenic Diabetes Insipidus (Central Diabetes Insipidus) 01/2018
1	Colonic Neoplasms (Colon Cancer) 12/2017
1	Urinary Bladder Calculi (Bladder Calculi) 12/2017
1	Stroke (Strokes) 10/2016
1	Thrombosis (Thrombus) 10/2016
1	Heart Failure 12/2015
1	Glomerulonephritis 12/2015
1	Brain Ischemia (Cerebral Ischemia) 02/2015
1	Infarction (Infarctions) 02/2015
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 02/2015
1	Cerebral Infarction 01/2015

Drug/Important Bio-Agent (IBA)

8	Messenger RNA (mRNA)IBA 12/2013 - 06/2002
6	Phosphotransferases (Kinase)IBA 01/2020 - 01/2009
6	Tyrosine (L-Tyrosine)FDA Link 01/2020 - 02/2009
6	Temozolomide (Temodar)FDA LinkGeneric 02/2015 - 02/2009
5	AcidsIBA 03/2017 - 10/2006
5	Proteins (Proteins, Gene)FDA Link 10/2014 - 03/2005
4	Glycogen Synthase KinasesIBA 04/2017 - 02/2009
4	Biological ProductsIBA 04/2017 - 08/2011
4	MethyltransferasesIBA 10/2013 - 11/2010
3	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2020 - 05/2010
3	ErbB Receptors (EGF Receptor)IBA 01/2020 - 05/2010
3	Pharmaceutical PreparationsIBA 04/2017 - 12/2007
3	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 02/2007 - 06/2002
3	beta CateninIBA 02/2007 - 07/2003
3	Ergonovine (Ergometrine)IBA 12/2004 - 09/2003
2	Erythropoietin FDA Link 01/2020 - 01/2013
2	Discoidin Domain Receptor 1IBA 01/2020 - 01/2013
2	tyrosine receptor (receptor, tyrosine)IBA 01/2020 - 01/2013
2	Glutamic Acid (Glutamate)FDA Link 07/2015 - 07/2014
2	Glycogen Synthase (Synthase I)IBA 02/2015 - 10/2013
2	MRK 003IBA 01/2015 - 02/2013
2	AntibodiesIBA 10/2014 - 02/2009
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 07/2014 - 10/2013
2	EphrinsIBA 12/2013 - 11/2011
2	LigandsIBA 12/2013 - 11/2011
2	N- (4- methoxybenzyl)- N'- (5- nitro- 1,3- thiazol- 2- yl)ureaIBA 10/2013 - 02/2009
2	Small Interfering RNA (siRNA)IBA 10/2013 - 05/2010
2	Alkylating AgentsIBA 01/2012 - 02/2011
2	Sphingosine-1-Phosphate ReceptorsIBA 05/2010 - 05/2010
2	Inosine Triphosphate (ITP)IBA 11/2009 - 01/2002
2	Pentetic Acid (DTPA)FDA LinkGeneric 12/2007 - 10/2003
2	CreatinineIBA 12/2007 - 10/2006
2	Acetylcholine (Acetylcholine Chloride)FDA Link 12/2004 - 09/2003
2	Phenobarbital (Luminal)FDA Link 12/2004 - 09/2003
1	Capsules (Microcapsules)IBA 01/2020
1	Tumor Biomarkers (Tumor Markers)IBA 12/2017
1	Carcinoembryonic AntigenIBA 12/2017
1	AnticoagulantsIBA 10/2016
1	CreatineIBA 07/2015
1	Protons (Proton)IBA 07/2015
1	JNK Mitogen-Activated Protein KinasesIBA 02/2015
1	Focal Adhesion Protein-Tyrosine KinasesIBA 02/2015
1	Glucose (Dextrose)FDA LinkGeneric 02/2015
1	Transcription Factors (Transcription Factor)IBA 02/2015
1	Molecular Chaperones (Chaperone, Molecular)IBA 02/2015
1	Carmustine (FIVB)FDA Link 01/2015
1	poliferprosan 20 drug combination carmustine (Gliadel)FDA Link 01/2015

Therapy/Procedure

13	Therapeutics 01/2020 - 01/2002
4	Craniotomy 01/2020 - 11/2004
3	Drug Therapy (Chemotherapy) 01/2012 - 05/2003
3	Aftercare (After-Treatment) 07/2011 - 12/2004
3	Liver Transplantation 12/2004 - 02/2003
2	Operative Surgical Procedures 10/2016 - 01/2015
2	Radiotherapy 01/2012 - 11/2010
2	Replantation 12/2007 - 10/2006
1	Sutures (Suture) 07/2021
1	Pancreaticoduodenectomy 07/2021
1	Hormone Replacement Therapy (Therapy, Hormone Replacement) 01/2018
1	Photochemotherapy (Photodynamic Therapy) 03/2017
1	Carotid Endarterectomy 10/2016
1	Renal Dialysis (Hemodialysis) 12/2015